https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12477 Sat 24 Mar 2018 08:17:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10268 Sat 24 Mar 2018 08:13:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21473 Sat 24 Mar 2018 08:03:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21562 Sat 24 Mar 2018 07:59:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20903 Sat 24 Mar 2018 07:57:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19855 Sat 24 Mar 2018 07:57:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21121 Sat 24 Mar 2018 07:54:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27963 Sat 24 Mar 2018 07:38:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28102 Sat 24 Mar 2018 07:24:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26915 T, MTHFR 1298A>C, MTRR 66A>G, MTR 2756 A>G, MTR 5049 C>A, CBS 844 Ins68, and CBS 2199 T>C) were genotyped in children and their parents. Information on prepregnancy maternal folic acid supplement use was collected. ORs were estimated with unconditional logistic regression adjusted for frequency-matched variables and potential confounders. Case-parent trios were also analyzed. Results: There was some evidence of a reduced risk of ALL among children who had, or whose father had, the MTRR 66GG genotype: ORs 0.60 [95% confidence interval (CI) 0.39-0.91] and 0.64 (95% CI, 0.40-1.03), respectively. The ORs for paternal MTHFR 677CT and TT genotypes were 1.41 (95% CI, 1.02-1.93) and 1.81 (95% CI, 1.06-3.07). ORs varied little by maternal folic acid supplementation. Conclusions: Some folate pathway gene polymorphisms in the child or a parent may influence ALL risk. While biologically plausible, underlying mechanisms for these associations need further elucidation. Impact: Folate pathway polymorphisms may be related to risk of childhood ALL, but larger studies are needed for conclusive results.]]> Sat 24 Mar 2018 07:23:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23994 Sat 24 Mar 2018 07:10:24 AEDT ]]>